Translating Membrane Proteins Into Therapeutics; From Bedside to Bench

Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study

S Liu, I Agartz, P Allen, GP Amminger, OA Andreassen, P Bachman, I Baeza, H Baldwin, CF Bartholomeusz, S Borgwardt, S Catalano, X Chen, KIK Cho, S Choi, T Colibazzi, RE Cooper, CM Corcoran, VL Cropley, L de Haan, C de la Fuente-Sandoval

2026-03-01

Brain network architecture is anticipated to influence future grey matter loss in individuals at Clinical High Risk (CHR) for psyc..

Temperament mediates the relationship between family environment and psychotic-like experiences in early adolescence: Findings from the ABCD study

AJ Thompson, R Marie, B Tonge, C Pantelis, CMJ Wannan

2025-12-01

Background Psychotic-Like Experiences (PLEs) during early adolescence may precede development of later psychotic disorders. Given ..

Examination of mitochondria- and inflammasome-mediated mechanisms of clozapine-induced myocarditis using patient-derived iPSC cardiomyocytes

N Vaziri, TE Shutt, W Karim, TJ Raedler, C Pantelis, N Thomas, M Jayaram, SC Greenway, CA Bousman

2025-08-01

Clozapine is the only approved pharmacotherapy for treatment-resistant schizophrenia. However, widespread utilization of clozapine..

Associations between structural brain changes and blood neurofilament light chain protein in treatment-resistant schizophrenia

BJ Cilia, D Eratne, C Wannan, C Malpas, S Janelidze, O Hansson, I Everall, C Bousman, N Thomas, AF Santillo, D Velakoulis, C Pantelis

2025-03-01

Objective: Around 30% of people with schizophrenia are refractory to antipsychotic treatment (treatment-resistant schizophrenia). ..

Implications of the choroid plexus in Niemann-Pick disease Type C neuropathogenesis

R van Gool, M Cay, B Ren, K Brodeur, E Golden, B Goodlett, E Yang, T Reilly, C Hastings, EM Berry-Kravis, PY Lee, M Di Biase, V Cropley, C Pantelis, D Velakoulis, AK Shinn, W Al-Hertani, M Walterfang, J Upadhyay

2025-02-01

Background: Niemann-Pick Disease Type C (NPC) is an ultra-rare disorder characterized by progressive psychiatric and neurologic ma..

Characterising grey-white matter relationships in recent-onset psychosis and its association with cognitive function

Y Saito, C Pantelis, V Cropley, L Laskaris, CMJ Wannan, WT Syeda

2025-01-01

Individuals with recent-onset psychosis (ROP) present widespread grey matter (GM) reductions and white matter (WM) abnormalities. ..

Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders

Dhamidhu Eratne, Matthew JY Kang, Courtney Lewis, Christa Dang, Charles Malpas, Suyi Ooi, Amy Brodtmann, David Darby, Henrik Zetterberg, Kaj Blennow, Michael Berk, Olivia Dean, Chad Bousman, Naveen Thomas, Ian Everall, Chris Pantelis, Cassandra Wannan, Claudia Cicognola, Oskar Hansson, Shorena Janelidze

2024-12-15

OBJECTIVE: Timely, accurate distinction between behavioural variant frontotemporal dementia (bvFTD) and primary psychiatric disord..

Positive allosteric modulation of a GPCR ternary complex

WAC Burger, CJ Draper-Joyce, C Valant, A Christopoulos, DM Thal

2024-09-13

The activation of a G protein–coupled receptor (GPCR) leads to the formation of a ternary complex between agonist, receptor, and G..

Brain region-specific alterations in gene expression trajectories in the offspring born from influenza A virus infected mice

Stella Liong, KH Christopher Choy, Simone N De Luca, Felicia Liong, Madison Coward-Smith, Osezua Oseghale, Mark A Miles, Ross Vlahos, Celine Valant, Jess Nithianantharajah, Christos Pantelis, Arthur Christopoulos, Stavros Selemidis

2024-08-01

Influenza A virus (IAV) infection during pregnancy can increase the risk for neurodevelopmental disorders in the offspring, howeve..

The role of the adenosine system in epilepsy and its comorbidities

JA Baltos, PM Casillas-Espinosa, B Rollo, KJ Gregory, PJ White, A Christopoulos, P Kwan, TJ O'Brien, LT May

2024-07-01

Epilepsy is one of the most serious and common chronic neurological conditions, characterised by recurrent hypersynchronous electr..

Plasma neurofilament light chain is not elevated in people with first-episode psychosis or those at ultra-high risk for psychosis

Matthew JY Kang, Dhamidhu Eratne, Cassandra Wannan, Alexander F Santillo, Dennis Velakoulis, Christos Pantelis, Vanessa Cropley

2024-05-01

Introduction: Neurofilament light chain (NfL), a blood biomarker of neuronal injury, shows promise in distinguishing neurodegenera..

Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3

Isabella C Russell, Xin Zhang, Fabian Bumbak, Samantha M McNeill, Tracy M Josephs, Michael G Leeming, George Christopoulos, Hariprasad Venugopal, Maria M Flocco, Patrick M Sexton, Denise Wootten, Matthew J Belousoff

2024-02-20

The class A orphan G protein-coupled receptor (GPCR), GPR3, has been implicated in a variety of conditions, including Alzheimer’s ..

Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers

R Boen, T Kaufmann, D van der Meer, O Frei, I Agartz, D Ames, M Andersson, NJ Armstrong, E Artiges, JR Atkins, J Bauer, F Benedetti, DI Boomsma, H Brodaty, K Brosch, RL Buckner, MJ Cairns, V Calhoun, S Caspers, S Cichon

2024-01-15

Background: Carriers of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants exhibit regional and global brain differences c..

Normative Modeling of Brain Morphometry in Clinical High Risk for Psychosis

SS Haas, R Ge, I Agartz, GP Amminger, OA Andreassen, P Bachman, I Baeza, S Choi, T Colibazzi, VL Cropley, C De La Fuente-Sandoval, BH Ebdrup, A Fortea, P Fusar-Poli, BY Glenthøj, LB Glenthøj, KM Haut, RA Hayes, K Heekeren, CI Hooker

2024-01-03

Importance: The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A com..

Gross anatomical features of the insular cortex in affective disorders

T Takahashi, D Sasabayashi, M Yücel, S Whittle, M Suzuki, C Pantelis, GS Malhi, NB Allen

2024-01-01

Introduction: The number of insular gyri is elevated in patients with schizophrenia. Thus, it has potential as a marker of early n..

Apicobasal RNA asymmetries regulate cell fate in the early mouse embryo

A Hawdon, ND Geoghegan, M Mohenska, A Elsenhans, C Ferguson, JM Polo, RG Parton, J Zenker

2023-12-01

The spatial sorting of RNA transcripts is fundamental for the refinement of gene expression to distinct subcellular regions. Altho..

Gradients of striatal function in antipsychotic-free first-episode psychosis and schizotypy

M Oldehinkel, J Tiego, K Sabaroedin, S Chopra, SM Francey, B O’Donoghue, V Cropley, B Nelson, J Graham, L Baldwin, HP Yuen, K Allott, M Alvarez-Jimenez, S Harrigan, C Pantelis, SJ Wood, P McGorry, MA Bellgrove, A Fornito

2023-12-01

Both psychotic illness and subclinical psychosis-like experiences (PLEs) have been associated with cortico-striatal dysfunction. T..

Investigation of brain iron in anorexia nervosa, a quantitative susceptibility mapping study

P Ravanfar, RJ Rushmore, AE Lyall, V Cropley, N Makris, P Desmond, D Velakoulis, ME Shenton, AI Bush, SL Rossell, C Pantelis, WT Syeda, A Phillipou

2023-12-01

Background: Anorexia nervosa (AN) is a potentially fatal psychiatric condition, associated with structural brain changes such as g..

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

WAC Burger, V Pham, Z Vuckovic, AS Powers, JI Mobbs, Y Laloudakis, A Glukhova, D Wootten, AB Tobin, PM Sexton, SM Paul, CC Felder, R Danev, RO Dror, A Christopoulos, C Valant, DM Thal

2023-12-01

The M<inf>4</inf> muscarinic acetylcholine receptor (M<inf>4</inf> mAChR) has emerged as a drug target of high therapeutic interes..

Complement proteins are elevated in blood serum but not CSF in clinical high-risk and antipsychotic-naïve first-episode psychosis

VL Cropley, M Kittel, M Heurich, M Föcking, FM Leweke, C Pantelis

2023-10-01

Alterations in the complement system have been reported in some people with psychotic disorder, including in pre-psychotic individ..

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

GT Nguyen-Dien, KL Kozul, Y Cui, B Townsend, PG Kulkarni, SS Ooi, A Marzio, N Carrodus, S Zuryn, M Pagano, RG Parton, M Lazarou, SS Millard, RW Taylor, BM Collins, MJK Jones, JK Pagan

2023-07-03

To maintain both mitochondrial quality and quantity, cells selectively remove damaged or excessive mitochondria through mitophagy,..

Investigation of Brain Iron in Niemann-Pick Type C: A 7T Quantitative Susceptibility Mapping Study

P Ravanfar, WT Syeda, RJ Rushmore, B Moffat, AE Lyall, AH Merritt, GA Devenyi, MM Chakravarty, P Desmond, VL Cropley, N Makris, ME Shenton, AI Bush, D Velakoulis, C Pantelis, M Walterfang

2023-07-01

BACKGROUND AND PURPOSE: While brain iron dysregulation has been observed in several neurodegenerative disorders, its association w..

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Z Vuckovic, J Wang, V Pham, JI Mobbs, MJ Belousoff, A Bhattarai, WAC Burger, G Thompson, M Yeasmin, V Nawaratne, K Leach, ET van der Westhuizen, E Khajehali, YL Liang, A Glukhova, D Wootten, CW Lindsley, A Tobin, P Sexton, R Danev

2023-05-30

Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a..

A Meta-analysis of Mental Time Travel in Individuals with Autism Spectrum Disorders

Jun-yan Ye, Xiao-jing Qin, Ji-fang Cui, Qian Ren, Lu-xia Jia, Ya Wang, Christos Pantelis, Raymond CK Chan

2023-04-13

Autism spectrum disorders (ASD) are associated with cognitive dysfunctions, including mental time travel (MTT). However, findings ..

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

LI Labzin, KY Chew, K Eschke, X Wang, T Esposito, CJ Stocks, J Rae, R Patrick, H Mostafavi, B Hill, TE Yordanov, CL Holley, S Emming, S Fritzlar, FL Mordant, DP Steinfort, K Subbarao, CM Nefzger, AK Lagendijk, EJ Gordon

2023-04-01

Macrophages are key cellular contributors to the pathogenesis of COVID-19, the disease caused by the virus SARS-CoV-2. The SARS-Co..

Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2

Y Wu, YW Lim, DA Stroud, N Martel, TE Hall, HP Lo, C Ferguson, MT Ryan, KA McMahon, RG Parton

2023-03-13

Caveolae have been linked to many biological functions, but their precise roles are unclear. Using quantitative whole-cell proteom..

Increased prevalence of the Heschl's gyrus duplication pattern common to various first-episode psychoses

T Takahashi, D Sasabayashi, SJ Wood, PD McGorry, M Suzuki, D Velakoulis, C Pantelis

2023-02-01

Affinity scores: An individual-centric fingerprinting framework for neuropsychiatric disorders

CMJ Wannan, C Pantelis, AH Merritt, B Tonge, WT Syeda

2022-12-01

Population-centric frameworks of biomarker identification for psychiatric disorders focus primarily on comparing averages between ..

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

G Deganutti, YL Liang, X Zhang, M Khoshouei, L Clydesdale, MJ Belousoff, H Venugopal, TT Truong, A Glukhova, AN Keller, KJ Gregory, K Leach, A Christopoulos, R Danev, CA Reynolds, P Zhao, PM Sexton, D Wootten

2022-12-01

The glucagon-like peptide-1 receptor (GLP-1R) has broad physiological roles and is a validated target for treatment of metabolic d..

In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia

P Ravanfar, WT Syeda, M Jayaram, RJ Rushmore, B Moffat, AP Lin, AE Lyall, AH Merritt, N Yaghmaie, L Laskaris, S Luza, CM Opazo, B Liberg, MM Chakravarty, GA Devenyi, P Desmond, VL Cropley, N Makris, ME Shenton, AI Bush

2022-12-01

Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidat..

Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis

H Baldwin, J Radua, M Antoniades, SS Haas, S Frangou, I Agartz, P Allen, OA Andreassen, K Atkinson, P Bachman, I Baeza, CF Bartholomeusz, MWL Chee, T Colibazzi, RE Cooper, CM Corcoran, VL Cropley, BH Ebdrup, A Fortea, LB Glenthøj

2022-12-01

Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. Howev..

Understanding VPAC receptor family peptide binding and selectivity

SJ Piper, G Deganutti, J Lu, P Zhao, YL Liang, Y Lu, MM Fletcher, MA Hossain, A Christopoulos, CA Reynolds, R Danev, PM Sexton, D Wootten

2022-12-01

The vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are key regulator..

Heschl’s gyrus duplication pattern and clinical characteristics in borderline personality disorder: A preliminary study

T Takahashi, D Sasabayashi, D Velakoulis, M Suzuki, PD McGorry, C Pantelis, AM Chanen

2022-11-03

Inter-individual variations in the sulco-gyral pattern of Heschl’s gyrus (HG) might contribute to emotional processing. However, i..

Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness

Cassandra MJ Wannan, Cali F Bartholomeusz, Christos Pantelis, Maria A Di Biase, Warda T Syeda, M Mallar Chakravarty, Chad A Bousman, Ian P Everall, Patrick D McGorry, Andrew Zalesky, Vanessa L Cropley

2022-09-01

Episodic memory ability relies on hippocampal-prefrontal connectivity. However, few studies have examined relationships between me..

Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Y Patel, J Shin, C Abé, I Agartz, C Alloza, D Alnæs, S Ambrogi, LA Antonucci, C Arango, V Arolt, G Auzias, R Ayesa-Arriola, N Banaj, T Banaschewski, C Bandeira, Z Başgöze, RB Cupertino, CHD Bau, J Bauer, S Baumeister

2022-08-15

Background: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental orig..

Different Frequency of Heschl’s Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders

T Takahashi, D Sasabayashi, M Yücel, S Whittle, V Lorenzetti, M Walterfang, M Suzuki, C Pantelis, GS Malhi, NB Allen

2022-06-13

An increased prevalence of duplicated Heschl’s gyrus (HG) has been repeatedly demonstrated in various stages of schizophrenia as a..

Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis

EP Hedges, H Dickson, S Tognin, G Modinos, M Antoniades, M van der Gaag, L de Haan, P McGorry, C Pantelis, A Riecher-Rössler, R Bressan, N Barrantes-Vidal, MO Krebs, M Nordentoft, S Ruhrmann, G Sachs, BP Rutten, J van Os, LR Valmaggia, P McGuire

2022-06-01

Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder...

Pattern of predictive features of continued cannabis use in patients with recent-onset psychosis and clinical high-risk for psychosis

Nora Penzel, Rachele Sanfelici, Linda A Antonucci, Linda T Betz, Dominic Dwyer, Anne Ruef, Kang Ik K Cho, Paul Cumming, Oliver Pogarell, Oliver Howes, Peter Falkai, Rachel Upthegrove, Stefan Borgwardt, Paolo Brambilla, Rebekka Lencer, Eva Meisenzahl, Frauke Schultze-Lutter, Marlene Rosen, Theresa Lichtenstein, Lana Kambeitz-Ilankovic

2022-03-09

Continued cannabis use (CCu) is an important predictor for poor long-term outcomes in psychosis and clinically high-risk patients,..

Characterization and interrelationships of theory of mind, socially competitive emotions and affective empathy in bipolar disorder

CK Lemvigh, JA Karantonis, LS Furlong, SP Carruthers, C Pantelis, SL Rossell, TE Van Rheenen

2022-03-01

Objective: Evidence shows impaired theory of mind (ToM) in patients with bipolar disorder (BD), yet research examining its cogniti..

Cortico-cognition coupling in treatment resistant schizophrenia

WT Syeda, CMJ Wannan, AH Merritt, JM Raghava, M Jayaram, D Velakoulis, TD Kristensen, RF Soldatos, S Tonissen, N Thomas, KS Ambrosen, ME Sørensen, B Fagerlund, E Rostrup, BY Glenthøj, E Skafidas, CA Bousman, LA Johnston, I Everall, BH Ebdrup

2022-01-01

Background: Brain structural alterations and cognitive dysfunction are independent predictors for poor clinical outcome in schizop..

Cognitive behavioral markers of neurodevelopmental trajectories in rodents

KHC Choy, JK Luo, CMJ Wannan, L Laskaris, A Merritt, WT Syeda, PM Sexton, A Christopoulos, C Pantelis, J Nithianantharajah

2021-12-01

Between adolescence and adulthood, the brain critically undergoes maturation and refinement of synaptic and neural circuits that s..

High intraluminal pressure promotes vascular inflammation via caveolin-1

DL Michell, WA Shihata, KL Andrews, NAZ Abidin, AM Jefferis, AK Sampson, NG Lumsden, O Huet, MO Parat, GL Jennings, RG Parton, KJ Woollard, DM Kaye, JPF Chin-Dusting, AJ Murphy

2021-12-01

The aetiology and progression of hypertension involves various endogenous systems, such as the renin angiotensin system, the sympa..

Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19

C Pantelis, M Jayaram, AJ Hannan, R Wesselingh, J Nithianantharajah, CMJ Wannan, WT Syeda, KC Choy, D Zantomio, A Christopoulos, D Velakoulis, TJ O’Brien

2021-08-01

Although COVID-19 is predominantly a respiratory disease, it is known to affect multiple organ systems. In this article, we highli..

Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis

N Penzel, LA Antonucci, LT Betz, R Sanfelici, J Weiske, O Pogarell, P Cumming, BB Quednow, O Howes, P Falkai, R Upthegrove, A Bertolino, S Borgwardt, P Brambilla, R Lencer, E Meisenzahl, M Rosen, T Haidl, L Kambeitz-Ilankovic, S Ruhrmann

2021-07-01

Cannabis use during adolescence is associated with an increased risk of developing psychosis. According to a current hypothesis, t..

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

KA McMahon, DA Stroud, Y Gambin, VA Tillu, M Bastiani, E Sierecki, M Polinkovsky, TE Hall, GA Gomez, Y Wu, MO Parat, N Martel, HP Lo, KK Khanna, K Alexandrov, R Daly, AS Yap, MT Ryan, RG Parton

2021-06-01

Caveolae-associated protein 3 (cavin3) is inactivated in most cancers. We characterized how cavin3 affects the cellular proteome u..

Brain-Predicted Age Associates With Psychopathology Dimensions in Youths

VL Cropley, Y Tian, K Fernando, S Mansour L., C Pantelis, L Cocchi, A Zalesky

2021-04-01

Background: This study aimed to investigate whether dimensional constructs of psychopathology relate to variation in patterns of b..

The Psychopathology and Neuroanatomical Markers of Depression in Early Psychosis

R Upthegrove, P Lalousis, P Mallikarjun, K Chisholm, SL Griffiths, M Iqbal, M Pelton, R Reniers, A Stainton, M Rosen, A Ruef, DB Dwyer, M Surman, T Haidl, N Penzel, L Kambeitz-Llankovic, A Bertolino, P Brambilla, S Borgwardt, J Kambeitz

2021-01-01

Depression frequently occurs in first-episode psychosis (FEP) and predicts longer-term negative outcomes. It is possible that this..

Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity

MJ Bywater, DL Burkhart, J Straube, A Sabò, V Pendino, JE Hudson, GA Quaife-Ryan, ER Porrello, J Rae, RG Parton, TR Kress, B Amati, TD Littlewood, GI Evan, CH Wilson

2020-12-01

It is unclear why some tissues are refractory to the mitogenic effects of the oncogene Myc. Here we show that Myc activation induc..

Structure and dynamics of the active Gs-coupled human secretin receptor

M Dong, G Deganutti, SJ Piper, YL Liang, M Khoshouei, MJ Belousoff, KG Harikumar, CA Reynolds, A Glukhova, SGB Furness, A Christopoulos, R Danev, D Wootten, PM Sexton, LJ Miller

2020-12-01

The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascu..

Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

X Zhang, MJ Belousoff, P Zhao, AJ Kooistra, TT Truong, SY Ang, CR Underwood, T Egebjerg, P Šenel, GD Stewart, YL Liang, A Glukhova, H Venugopal, A Christopoulos, SGB Furness, LJ Miller, S Reedtz-Runge, CJ Langmead, DE Gloriam, R Danev

2020-11-05

Zhang et al. show that the non-peptide GLP-1R agonist PF 06882961, but not CHU-128, was able to closely mimic the in vitro pharmac..

Schizotypal Disorder in Children - A Neglected Diagnosis

BJ Tonge, R Testa, C Díaz-Arteche, AV Brereton, K Stephanou, C Pantelis

2020-01-01

Disabling psychotic-like perceptions, thoughts, and behavior have long been recognized in children. These symptoms have an adverse..

Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion

JL Teo, VM Tomatis, L Coburn, AK Lagendijk, IM Schouwenaar, S Budnar, TE Hall, S Verma, RW McLachlan, BM Hogan, RG Parton, AS Yap, GA Gomez

2020-01-01

Epithelia can eliminate apoptotic cells by apical extrusion. This is a complex morphogenetic event where expulsion of the apoptoti..